The news was declared from the get-go Wednesday morning, in spite of an appeal to spare the club got 150,000 marks.
London Mayor Sadiq Khan said he was baffled at the news.
"London's famous clubs are a vital piece of our social scene," he said.
"Clubbing should be sheltered however I'm frustrated that Fabric, Islington Council and the Metropolitan Police were not able achieve concession to how to address worries about open wellbeing.
"As an aftereffect of this choice, a large number of individuals who delighted in going to Fabric as a fundamental piece of London's nightlife will miss out."
He said London had lost portion of its clubs and 40 for each penny of its unrecorded music venues in the course of the most recent eight years.
"This decay must stop if London is to hold its status as a 24-hour city with a world-class nightlife".
Agents of Fabric dance club had assembled at the gathering meeting to put forth their defense for the mainstream venue to stay open.
Be that as it may, the choice was made after police raised worries about medications on the premises and the passings of two youngsters from suspected overdoses.
A month ago the Met Police connected to the committee for the permit to be assessed in the midst of "worries about genuine wrongdoing" connected to the club.
DJ Jacob Husley, who has worked at the club's Sunday night party for as far back as eight years, said he was stunned and furious at the choice.
He said: "We are in stun. I am feeling a blend of doubt and outrage and pity.
"It would be an overwhelming blow for London and culture, and clubs over the UK. It sets a point of reference."
Mr Husley said he couldn't say whether the club's proprietors would advance however included that he trusted "we are not completed with this".
A representative for Fabric said: "Fabric is to a great degree disillusioned with Islington Council's choice to disavow our permit.
"This is a particularly tragic day for the individuals who have bolstered us, especially the 250 staff who will now lose their employments.
"Shutting Fabric is not the response to the medication related issues clubs like our own are attempting to forestall, and sets an upsetting point of reference for the eventual fate of London's evening time economy."
Leader of London Sadiq Khan had already said he was "resolved" to accomplish more to secure London's "famous clubs".
In any case, he said that City Hall did not have the ability to mediate in permitting cases like this one.
He asked everybody required to "locate a judgment skills arrangement that guarantees the club stays open while securing the wellbeing of the individuals who need to make the most of London's clubbing scene".
A representative for the Met said: "Police felt the need to act because of worries about the security of those going to the club because of the supply of class A medications in the venue and the late passings of two young fellows connected to the club.
"We bolster this choice made by Islington Council's authorizing board of trustees.
"London has an incredibly famous evening economy and individuals ought to have the capacity to appreciate it securely, without worries of genuine wrongdoing.
"The Met is focused on working in organization with those in charge of this part to guarantee this happens."